Side effects and risks of lipase inhibitors The most common side effects of orlistat are gastrointestinal, including: Loose, greasy stools Diarrhea Gas (flatulence) Leakage of feces (poop) onto underwear or clothes Abdominal pain Tears in the anus Because orlistat works by blocking fat absorption and removing excess fat as waste, these side effects may be more common after eating high-fat foods or meals
The available evidence on retatrutide's GI effects including its potential to alter bowel habits comes primarily from a Phase 2 clinical trial (Jastreboff et al., NEJM 2023)
What Trial Participants Get Free pharmaceutical-grade retatrutide for the duration of the trial Regular medical monitoring, lab work, and health assessments Compensation for time and travel (varies by site) Access to the latest trial data and results The tradeoff: You may receive placebo instead of retatrutide (most trials are randomized)
Managing Side Effects Without Quitting Side effects are where most people who do not successfully complete a Retatrutide protocol drop off
Vitamin B6 Vitamin B6 supports normal energy metabolism and nervous system function
A potential explanation of the difference in response between the two tests is that pro-C3 may be more indicative of active fibrogenesis, whereas ELF may correlate more with the severity of histological liver fibrosis 36,40
